At the beginning of the war, DeGraffenried (variantly spelled "DeGraffenriedt") was a physician, county coroner, and small slaveholder in Colorado County, Texas, where he and his brother Thomas Tscharner DeGraffenried, also a doctor, had moved ca. 1855. In 1859, he left medicine to serve as principal of Columbus Seminary which the next year evolved into Columbus High School. In the fall of 1860, DeGraffenreid left teaching to return to medicine.
On August 17, 1861, he enlisted as a private in Company A of the 5th Texas Cavalry. He was discharged on October 26, 1861 and the joined the Field & Staff of the 3rd TX Infantry as asssistant surgeon. Degraffenried resigned on May 30, 1862. He died in Columbus, Texas on December 3, 1867.
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